Unusual Incidence and Location of Renaut Bodies in Beagle Dogs in a Nonclinical Study. (April 2020)

• Record Type: Journal Article
• Authors: Nelissen, Sophie; Lensen, Joost; Barale-Thomas, Erio
• Is Part Of: Toxicologic pathology. Volume 48:Number 3(2020)
• Page Start: 524
• Page End: 528
• Publication Date: 2020-04
• Subjects: Beagle dog -- Renaut bodies -- adrenal gland -- sciatic nerve; Pathology -- Periodicals; Toxicology -- Periodicals; Pathology; Toxicology; 615.9
• DOI: 10.1177/0192623319896256
• Languages: English
• ISSNs: 0192-6233

Abstract

We identified the presence of Renaut bodies in an unusual location in Beagle dogs on a 3-month nonclinical toxicity study. These peculiar structures are commonly reported as a background finding in the sciatic nerve of dogs. In our study, however, they were also observed in autonomic nerves surrounding the adrenal gland, a location in which they have not been reported before. The incidence in both locations were 8 of 32 Beagle dogs in the sciatic nerve and 6 of 40 Beagle dogs around the adrenal gland in the dosing and/or recovery phases of the study.