Brain natriuretic peptide in pregnant women with heart disease. (March 2020)

• Record Type: Journal Article
• Authors: Singh, Karanvir; Sikka, Pooja; Suri, Vanita; Prasad, Rishikesh; Khullar, Madhu; Vijayvergiya, Rajesh
• Is Part Of: Obstetric medicine. Volume 13:Number 1(2020:Mar.)
• Page Start: 25
• Page End: 29
• Publication Date: 2020-03
• Subjects: Brain natriuretic peptide -- pregnancy -- heart disease; Pregnancy -- Complications -- Periodicals; Obstetrics -- Periodicals; 618.2
• DOI: 10.1177/1753495X18819351
• Languages: English
• ISSNs: 1753-495X

Abstract

Background: Plasma brain natriuretic peptide levels were prospectively studied in pregnant women with heart disease. Methods: Fifty pregnant women with heart disease and 25 controls were evaluated at 24 weeks or under, 30–32 weeks, 34 weeks or more of gestation, and 6 weeks postpartum. Adverse maternal cardiac events were hospitalization for worsening heart failure, stroke, and death. Results: Thirty-eight (76%) women had rheumatic heart disease. Plasma brain natriuretic peptide levels were (in cases and controls) 118.3 ± 46.5 pg/ml and 66.3 ± 15.9 pg/ml (at 24 weeks or under), 124.8 ± 30.4 pg/ml and 68.4 ± 16.5 pg/ml (30–32 weeks), 135.8 ± 34.9 pg/ml and 68.6 ± 15.6 pg/ml (34 weeks or more), and 110.1 ± 21.9 pg/ml and 65.0 ± 16.1 pg/ml (6 weeks postpartum) (p = .0001). Eighteen women had adverse events. Of these, only 1 had a level less than 100 pg/ml, 12 were between 100 and 200 pg/ml, and 5 more than 200 pg/ml. Conclusions: Plasma brain natriuretic peptide levels were higher in women with heart disease at all periods of gestation as well as six weeks postpartum. No woman with a plasma brain natriuretic peptide levels of 98 pg/ml or less had an adverse event.