Acute cardiotoxicity associated with alemtuzumab infusion for multiple sclerosis. (May 2020)

• Record Type: Journal Article
• Authors: Ahrabian, Dariush; Neill, Lorna; Bell, Robert; Leary, Siobhan M
• Is Part Of: Multiple sclerosis. Volume 26:Number 6(2020)
• Page Start: 735
• Page End: 737
• Publication Date: 2020-05
• Subjects: Alemtuzumab -- multiple sclerosis -- infusion reaction; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458519855725
• Languages: English
• ISSNs: 1352-4585

Abstract

Alemtuzumab infusion is rarely associated with serious cardiac toxicity. We report a case of acute troponin-negative chest pain with dynamic T-wave changes, immediately following first infusion of alemtuzumab in a patient with multiple sclerosis. The chest pain and ECG (electrocardiogram) changes improved with cessation of alemtuzumab and conservative management. The presumed cause was infusion-associated cytokine release, but the precise mechanism is unknown.