Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis. (May 2020)

• Record Type: Journal Article
• Authors: Brown, James William L; Chowdhury, Azmain; Kanber, Baris; Prados Carrasco, Ferran; Eshaghi, Arman; Sudre, Carole H; Pardini, Matteo; Samson, Rebecca S; van de Pavert, Steven HP; Wheeler-Kingshott, Claudia Gandini; Chard, Declan T
• Is Part Of: Multiple sclerosis. Volume 26:Number 6(2020)
• Page Start: 679
• Page End: 687
• Publication Date: 2020-05
• Subjects: Primary progressive multiple sclerosis -- secondary progressive multiple sclerosis -- magnetisation transfer ratio -- normal-appearing white matter; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458519841810
• Languages: English
• ISSNs: 1352-4585

Abstract

Background: In relapse-onset multiple sclerosis (MS), tissue abnormality – as assessed with magnetisation transfer ratio (MTR) imaging – is greater in the outer cortical and inner periventricular layers. The cause of this remains unknown but meningeal inflammation has been implicated, particularly lymphoid follicles, which are seen in secondary progressive (SP) but not primary progressive (PP) MS. Cortical and periventricular MTR gradients might, therefore, differ in PPMS and SPMS if these follicles are responsible. Objective: We assessed cortical and periventricular MTR gradients in PPMS, and compared gradients between people with PPMS and SPMS. Methods: Using an optimised processing pipeline, periventricular normal-appearing white matter and cortical grey-matter MTR gradients were compared between 51 healthy controls and 63 people with progressive MS (28 PPMS, 35 SPMS). Results: The periventricular gradient was significantly shallower in healthy controls (0.122 percentage units (pu)/band) compared to PPMS (0.952 pu/band, p < 0.0001) and SPMS (1.360 pu/band, p < 0.0001). The cortical gradient was also significantly shallower in healthy controls (−2.860 pu/band) compared to PPMS (−3.214 pu/band, p = 0.038) and SPMS (−3.328 pu/band, p = 0.016). Conclusion: Abnormal periventricular and cortical MTR gradients occur in both PPMS and SPMS, suggesting comparable underlying pathological processes.