Double trouble: myocardial infarction with non-obstructive coronary arteries as a presentation of Hughes syndrome in monozygotic twins. (April 2020)

• Record Type: Journal Article
• Authors: Djokovic, A; Stojanovich, L; Stanisavljevic, N; Popovic, M; Zdravkovic, M
• Is Part Of: Lupus. Volume 29:Number 5(2020)
• Page Start: 505
• Page End: 508
• Publication Date: 2020-04
• Subjects: Antiphospholipid syndrome -- systemic lupus erythematosus -- MINOCA; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1177/0961203320906267
• Languages: English
• ISSNs: 0961-2033

Abstract

Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a recently described, clinically significant entity, with prevalence rates ranging from 1% to 14% and a mean of 6% of all patients with myocardial infarction. Antiphospholipid syndrome (APS; Hughes syndrome) is characterized by the presence of antiphospholipid antibodies associated with thrombosis (arterial and/or venous) and/or pregnancy morbidity and could be the cause of MINOCA. Data on genetic predisposition to APS are scarce. The present study describes a unique case of monozygotic twin brothers who, at a young age, developed the same clinical presentation of APS. The diagnosis of APS was later confirmed, along with a diagnosis of systemic lupus erythematosus in one brother.