Duration of dual antiplatelet therapy in patients with acute coronary syndrome undergoing drug-eluting stent implantation: A meta-analysis. Issue 4 (April 2020)

• Record Type: Journal Article
• Authors: Geng, Xue; Zhang, Ya-Nan; Cui, Wei
• Is Part Of: Journal of international medical research. Volume 48:Issue 4(2020)
• Publication Date: 2020-04
• Subjects: Dual antiplatelet therapy -- drug-eluting stents -- acute coronary syndromes -- percutaneous coronary intervention -- coronary artery disease -- acute coronary syndrome -- cardiovascular -- cerebrovascular; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/0300060520915052
• Languages: English
• ISSNs: 0300-0605

Abstract

Objective: This meta-analysis was performed to evaluate the optimal discontinuation of dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation in acute coronary syndrome (ACS) patients. Methods: A systematic search was conducted without language restrictions using PubMed, the Cochrane Library, and Clinical Trials.gov from January 2008 to July 2019. Studies that met the following criteria were included: (1) randomized trials that compared DAPT durations of <12 months ("short DAPT") or ≥12 months ("long DAPT"); (2) studies that included data on patients with ACS; and (3) studies that included data on outcomes. The outcomes were pooled using the Mantel–Haenszel model, generating relative risk (RR) and 95% confidence intervals (CI). Statistical heterogeneity was evaluated using the Cochrane Q statistic P -value and I 2 value. Publication bias was assessed by visually inspecting the funnel plots. Results: Eight studies comprising 10, 537 participants were included in the analysis. The primary endpoint was not different between short-term and long-term DAPT (RR, 1.11; 95% CI, 0.92–1.34). Conclusion: A meta-analysis of the available evidence suggests that DAPT can be reduced to 3 or 6 months without increasing the risk of cardiovascular and cerebrovascular events in patients with ACS who are undergoing DES implantation.