Inhibition of Pathogen Adhesion by Bacterial Outer Membrane‐Coated Nanoparticles. (3rd July 2019)

• Record Type: Journal Article
• Authors: Zhang, Yue; Chen, Yijie; Lo, Christopher; Zhuang, Jia; Angsantikul, Pavimol; Zhang, Qiangzhe; Wei, Xiaoli; Zhou, Zhidong; Obonyo, Marygorret; Fang, Ronnie H.; Gao, Weiwei; Zhang, Liangfang
• Is Part Of: Angewandte Chemie. Volume 131:Number 33(2019)
• Page Start: 11526
• Page End: 11530
• Publication Date: 2019-07-03
• Subjects: Antiadhäsion -- Bakterienmembranen -- Biomimetische Nanopartikel -- Infektiöse Krankheiten -- Nanomedizin; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201906280
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Anti‐adhesion therapies interfere with the bacterial adhesion to the host and thus avoid direct disruption of bacterial cycles for killing, which may alleviate resistance development. Herein, an anti‐adhesion nanomedicine platform is made by wrapping synthetic polymeric cores with bacterial outer membranes. The resulting bacterium‐mimicking nanoparticles (denoted "OM‐NPs") compete with source bacteria for binding to the host. The "top‐down" fabrication of OM‐NPs avoids the identification of the adhesins and bypasses the design of agonists targeting these adhesins. In this study, OM‐NPs are made with the membrane of Helicobacter pylori and shown to bind with gastric epithelial cells (AGS cells). Treatment of AGS cells with OM‐NPs reduces H. pylori adhesion and such anti‐adhesion efficacy is dependent on OM‐NP concentration and its dosing sequence. Abstract : Ein neuer Konkurrent : Mit bakteriellen Außenmembranen beschichtete Nanopartikel (OM‐NPs) wirken als antiadhäsive Nanomedizin, die mit den Ausgangsbakterien um Bindungsstellen konkurriert und so die bakterielle Adhäsion an die Wirtzellen hemmt. OM‐NPs mit einer äußeren Helicobacter‐pylori ‐Membran inhibieren die Bindung der Bakterien an die Magen‐Epithelzellen und Magengewebe.