Non-steroidal anti-inflammatory drug effects on renal and cardiovascular function: from physiology to clinical practice. (May 2020)

• Record Type: Journal Article
• Authors: Cabassi, Aderville; Tedeschi, Stefano; Perlini, Stefano; Verzicco, Ignazio; Volpi, Riccardo; Gonzi, Gianluca; Canale, Stefano Del
• Is Part Of: European journal of preventive cardiology. Volume 27:Number 8(2020)
• Page Start: 850
• Page End: 867
• Publication Date: 2020-05
• Subjects: Non-steroidal anti-inflammatory drugs -- acute and chronic renal disease -- atrial fibrillation -- myocardial infarction -- heart failure -- arterial hypertension; Cardiovascular system -- Diseases -- Prevention -- Periodicals; Cardiac patients -- Rehabilitation -- Periodicals; 616.12
• DOI: 10.1177/2047487319848105
• Languages: English
• ISSNs: 2047-4873

Abstract

Excessive or inappropriate use of non-steroidal anti-inflammatory drugs can affect cardiovascular and renal function. Non-steroidal anti-inflammatory drugs, both non-selective and selective cyclooxygenase 2 inhibitors, are among the most widely used drugs, especially in the elderly, with multiple comorbidities. Exposition to a polypharmacy burden represents a favourable substrate for the onset of non-steroidal anti-inflammatory drug-induced deleterious effects. Cardiovascular and renal issues concerning the occurrence of myocardial infarction, atrial fibrillation, heart failure and arterial hypertension, as well as acute or chronic kidney damage, become critical for clinicians in their daily practice. We discuss current available knowledge regarding prostanoid physiology in vascular, cardiac and renal systems, pointing out potential negative non-steroidal anti-inflammatory drug-related issues in clinical practice.