Composite Hydrogels: Prolonged Local In Vivo Delivery of Stimuli‐Responsive Nanogels That Rapidly Release Doxorubicin in Triple‐Negative Breast Cancer Cells (Adv. Healthcare Mater. 4/2020). Issue 4 (19th February 2020)

• Record Type: Journal Article
• Authors: Zhang, Yi; Dosta, Pere; Conde, João; Oliva, Nuria; Wang, Mian; Artzi, Natalie
• Is Part Of: Advanced healthcare materials. Volume 9:Issue 4(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-02-19
• Subjects: breast cancer -- composite hydrogels -- dual sensitive nanogels -- pH sensitivity -- redox sensitivity; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202070011
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : In article number 1901101 by Natalie Artzi and co‐workers, dual‐sensitive nanogels rapidly dislodge the chemotherapy drug inside cancer cells through pH and redox sensitivities, enabling efficient cancer‐cell killing. Their incorporation into an injectable hydrogel, delivered to tumor‐adjacent areas, enables prolonged release of the nanogels, with instantaneous action once taken up by cancer cells, resulting in increased therapeutic efficacy.