Impact of Diabetes Mellitus on Critical Limb Ischemia With Below the Knee Disease: Japan Below-the-Knee Artery Treatment Subanalysis. (May 2020)

• Record Type: Journal Article
• Authors: Suzuki, Kenji; Iida, Osamu; Yamauchi, Yasutaka; Nakano, Masatsugu; Soga, Yoshimitsu; Kawasaki, Daizo; Tazaki, Junichi; Yamaoka, Terutoshi; Suematsu, Nobuhiro; Shintani, Yoshiaki; Miyashita, Yusuke; Inoue, Naoto; Meguro, Taiichiro
• Is Part Of: Angiology. Volume 71:Number 5(2020)
• Page Start: 444
• Page End: 451
• Publication Date: 2020-05
• Subjects: endovascular therapy -- peripheral arterial disease -- diabetes mellitus -- critical limb ischemia; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319713499606
• Languages: English
• ISSNs: 0003-3197

Abstract

Background: A strong association exists between diabetes mellitus and critical limb ischemia. Methods and Results: We performed endovascular therapy on 1060 limbs in 884 patients with below knee lesions only. The patients were divided into diabetes (DG) and nondiabetes groups (NDG). Limb salvage was poorer in the DG (79% vs 89%, P = .0061). No significant difference was observed in mortality, amputation-free survival (AFS), and target vessel revascularization (TVR). Multivariate analysis revealed diabetes status, infection, poor activity of daily living (ADL), younger age, and procedure failure as independent predictors of major amputation in DG. In the NDG, procedure failure was the predictor, and younger age and poor ADL showed tendency of major amputation. Conclusions: Mortality, AFS, and TVR showed no significant difference between the 2 groups, but major amputation was more frequent in DG. Not only revascularization but also infection and diabetes control were very important for limb salvage in DG.