Synthetic Osteogenic Matrix using Polymeric Dendritic Peptides for treating Human Periodontal defects – design and in vitro evaluation. (2019)

• Record Type: Journal Article
• Authors: Das, Eva C.; Babu, Jisha; Dhawan, Sameer; Kumar PR, Anil; Kumary, T.V.; Haridas, V.; Komath, Manoj
• Is Part Of: Materials today. Volume 15:Part 2(2019)
• Page Start: 199
• Page End: 216
• Publication Date: 2019
• Subjects: Guanidine -- Peptides -- Polydiacetylenes -- Directed self assembly -- ECM mimetic -- Periodontal ligament cells -- Cell homing; Materials science -- Congresses -- Periodicals; 620.1
• DOI: 10.1016/j.matpr.2019.04.192
• Languages: English
• ISSNs: 2214-7853

Abstract

Abstract: Functional peptide molecules or their component functional moieties can be appended to self assembling polymers to mimic the extracellular matrix (ECM) and bring about predictable cell responses. Terminal guanidine functional group renders positive charge to the amino acid arginine, a component of the cell adhesive peptide Arginylglycylaspartic acid (RGD). We present the design and synthesis of guanidine appended polydiacetylene (G-PDA) as a cell adhesive matrix. Human periodontal ligament cell adhesion and differentiation on G-PDA matrix was evaluated to assess the feasibility of using the matrix for endogenous cell homing in periodontal regeneration. Guanidine appended polydiacetylene matrix proves to be a good substrate for cell homing, proliferation and differentiation. A well-designed scaffold using this material can lead to the regeneration of the periodontal bone.