Inside Back Cover: Asymmetric Hydrocyanation of Alkenes without HCN (Angew. Chem. Int. Ed. 32/2019). Issue 32 (24th July 2019)

• Record Type: Journal Article
• Authors: Li, Xiuxiu; You, Cai; Yang, Jiaxin; Li, Shuailong; Zhang, Dequan; Lv, Hui; Zhang, Xumu
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 32(2019)
• Page Start: 11125
• Page End: 11125
• Publication Date: 2019-07-24
• Subjects: asymmetric synthesis -- hydrocyanation -- hydroformylation -- nitriles -- rhodium; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201908626
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : An asymmetric cyanide‐free hydrocyanation of alkenes has been developed and described by H. Lv, X. Zhang and co‐workers in their Communication on page 10928 ff. Based on the asymmetric hydroformylation/condensation/aza‐Cope elimination sequences, a broad scope of substrates including mono‐substituted, 1, 2‐ and 1, 1‐disubstituted alkenes were employed, and a series of valuable chiral nitriles were prepared with high yields (up to 95%) and enantioselectivities (up to 98% ee).