Carbonylation of C−N Bonds in Tertiary Amines Catalyzed by Low‐Valent Iron Catalysts. Issue 32 (3rd July 2019)

• Record Type: Journal Article
• Authors: Nasr Allah, Tawfiq; Savourey, Solène; Berthet, Jean‐Claude; Nicolas, Emmanuel; Cantat, Thibault
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 32(2019)
• Page Start: 10884
• Page End: 10887
• Publication Date: 2019-07-03
• Subjects: amides -- carbon monoxide -- carbonylation -- iron -- Lewis acids; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201903740
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: The first iron catalysts able to promote the formal insertion of CO into the C−N bond of amines are reported. Using low‐valent iron complexes, including K2 [Fe(CO)4 ], amides are formed from aromatic and aliphatic amines, in the presence of an iodoalkane promoter. Inorganic Lewis acids, such as AlCl3 and Nd(OTf)3, have a positive influence on the catalytic activity of the iron salts, enabling the carbonylation at a low pressure of CO (6 to 8 bars). Abstract : No pressure : Low‐valent iron complexes, such as K2 [Fe(CO)4 ], efficiently catalyze the carbonylation of C−N bonds in amines by CO insertion. Lewis acids such as AlCl3 and Nd(OTf)3 have a positive influence on the catalytic activity and enable the carbonylation at a low pressure of CO.