NR4A2 genetic variation and Parkinson's disease: Evidence from a systematic review and meta-analysis. (22nd May 2017)

• Record Type: Journal Article
• Authors: Liu, Hongmei; Liu, Hongbo; Li, Ting; Cui, Jiayi; Fu, Yingmei; Ren, Juanjuan; Sun, Xiujia; Jiang, Ping; Yu, Shunying; Li, Chunbo
• Is Part Of: Neuroscience letters. Volume 650(2017)
• Page Start: 25
• Page End: 32
• Publication Date: 2017-05-22
• Subjects: Parkinson's disease (PD) -- NR4A2 -- Systematic review -- Meta-analysis; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2017.01.062
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: Comprehensively quantified the impact of all the reported 24 variants of NR4A2 on Parkinson's disease risk. Made a comprehensive meta-analysis of 2 SNPs (rs35479735 and rs12803) in case–control studies. The NR4A2 rs35479735 polymorphisms significantly associated with PD risk. Abstract: Introduction: The homo sapiens nuclear receptor subfamily 4, group A ( NR4A2 ) genetic variation has been implicated as a risk factor for Parkinson's disease (PD). Nevertheless, the results are inconclusive. We conducted a comprehensive systematic review and meta-analysis to quantify the impact of NR4A2 variation on the risk of PD. Methods: All eligible case–control studies published up to June 2016 by searching Pubmed, OVID, EBSCO, PsycINFO, ISI Web of Knowledge, Chinese Biomedical Literature Database and China Academic Journals Database were identified. Pooled odds ratio (OR) with 95% confidence interval (CI) were used to access the strength of the association in fixed- or random-effects model. Results: Eighteen studies reported 24 genetic variants with a total of 6150 cases and 5919 controls were included. Twelve studies for NR4A2 rs35479735 polymorphism and 4 studies for rs12803 were available for meta-analysis. A significant association was observed for rs35479735 under the homozygous model (OR = 1.31, 95% CI: 1.10–1.56, P = 0.003), whereas no significant association for rs12803 was detected. In subgroup analysis stratified by ethnicity, age onset and familial history, we found no significant association except one in sporadic PD subgroup under the recessive (OR = 3.30, 95% CI: 1.23–8.84, P = 0.02) and homozygous model (OR = 3.43, 95% CI: 1.26–9.33, P = 0.02) for rs35479735. Conclusion: The study comprehensively evaluated the association of NR4A2 variation with PD, and the results failed to demonstrate that the NR4A2 polymorphisms significantly associated with PD except for rs35479735, suggesting that more studies are needed to elucidate if NR4A2 is a risk of PD.