Kidney graft failure induced by BKPyV replication despite a strong reduction of the immunosuppressive therapy. Issue 9 (25th March 2019)

• Record Type: Journal Article
• Authors: Anselmo, Alessandro; Prezioso, Carla; Saccà, Filippo Antonino; Di Lella, Federica Maria; Palmieri, Giampiero; Tisone, Giuseppe; Pietropaolo, Valeria; Ciotti, Marco
• Is Part Of: Journal of medical virology. Volume 91:Issue 9(2019)
• Page Start: 1698
• Page End: 1701
• Publication Date: 2019-03-25
• Subjects: BKPyV -- immunosuppressive therapy -- kidney transplant -- noncoding control region (NCCR) -- PVAN -- VP1; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.25458
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract: BKPyV replication is a risk factor for the development of polyomavirus‐associated nephropathy in kidney transplant recipients. Here, the case of a 42 years old Caucasian patient is described who developed a kidney allograft failure because of uncontrolled BKPyV replication 7 months after transplant despite a strong reduction of the immunosuppressive therapy. The genetic analysis of the noncoding control region did not show rearrangement but two point mutations at nucleotide positions 18 and 31 within P block. The mutation at position 31 involved the nuclear factor‐1 site. Sequencing of the VP1 region revealed a subtype I/subgroup b‐1. Highlights: Uncontrolled replication of BKPyV can cause PyVAN in Kidney transplant patients. Reduction of immunosuppressive therapy usually allows to control BKPyV replication. Here, PyVAN develops despite reduction of immunosuppressive therapy. No significant genetic changes were found in VP1 gene and NCCR of the virus.