Cytomegalovirus ulcers following radiotherapy for a Marjolin ulcer in a renal transplant recipient. (6th September 2018)

• Record Type: Journal Article
• Authors: Wang, Charlie Y; Mulley, William R; Dendle, Claire; Mar, Adrian
• Is Part Of: Australasian journal of dermatology. Volume 60:Number 2(2019)
• Page Start: e145
• Page End: e147
• Publication Date: 2018-09-06
• Subjects: cytomegalovirus -- Marjolin ulcer -- radiotherapy -- skin -- transplant; Dermatology -- Periodicals; Dermatology -- Australasia -- Periodicals; 616.5005
• DOI: 10.1111/ajd.12921
• Languages: English
• ISSNs: 0004-8380

Abstract

Abstract: Cytomegalovirus (CMV) infection represents a major cause of morbidity and mortality in immunocompromised hosts. Skin ulceration is a rare manifestation of tissue‐invasive disease, with the anogenital region being the most typical site of involvement. We present a case of CMV ulceration on the right leg occurring 16 years following renal transplantation and 1 year after adjuvant radiotherapy for a Marjolin ulcer at this site. We suggest radiotherapy may provide a mechanism for local reactivation of the virus in the skin of seropositive patients.