Effect of sub-chronic ferrous sulfate treatment on motor skills, hematological and biochemical parameters in rats. Issue 4 (4th July 2019)

• Record Type: Journal Article
• Authors: Ammari, Mohamed; Elferchichi, Miryam; Othman, Haifa; Sakly, Mohsen; Abdelmelek, Hafedh
• Is Part Of: Archives of environmental & occupational health. Volume 74:Issue 4(2019)
• Page Start: 179
• Page End: 184
• Publication Date: 2019-07-04
• Subjects: Hematological parameters -- iron -- motor skills -- rats -- transferrin; Medicine, Preventive -- Periodicals; Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; Occupational diseases -- Periodicals; Environmental Health -- Periodicals; Occupational Medicine -- Periodicals; 616.9803
• DOI: 10.1080/19338244.2017.1395788
• Languages: English
• ISSNs: 1933-8244

Abstract

ABSTRACT: This study investigated the effects of ferrous sulfate (FeSO4) on motor skills, hematological and biochemical parameters in rats. Adult rats were treated with dose of iron (280 mg/L, per os ) for 15 consecutive days in drinking water. No significant difference was noticed for the motor skills in the stationary beam ( p = 0.23) and suspended string tests ( p = 0.48) between control and iron-treated rats. However, iron-treated rats showed a significant increase in white blood cells count ( p = 0.01), mean corpuscular volume values ( p = 0.02) and decrease in frequency of peristaltic contractions of the fragment of the intestine (in vitro) compared to control rats ( p = 0.01). No significant difference in plasma iron level ( p = 0.89) and transferrin amount were observed after iron treatment ( p = 0.65). The findings indicate that iron treatment at 280 mg/L, per os for 15 consecutive days in adult rats induced increase of hematological parameters (sign of a potential inflammation), but not motor skills deficit.