Cover Feature: Synthesis of the Core Oligosaccharides of Lipooligosaccharides from Campylobacter jejuni: A Putative Cause of Guillain–Barré Syndrome (Chem. Eur. J. 3/2019). Issue 3 (13th December 2018)

• Record Type: Journal Article
• Authors: Yoshida, Fumi; Yoshinaka, Hiroki; Tanaka, Hidenori; Hanashima, Shinya; Yamaguchi, Yoshiki; Ishihara, Mikio; Saburomaru, Miyuki; Kato, Yuki; Saito, Risa; Ando, Hiromune; Kiso, Makoto; Imamura, Akihiro; Ishida, Hideharu
• Is Part Of: Chemistry. Volume 25:Issue 3(2019)
• Page Start: 659
• Page End: 659
• Publication Date: 2018-12-13
• Subjects: carbohydrates -- gangliosides -- glycosylation -- Guillain–Barré syndrome -- lipooligosaccharides; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201805524
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : This artwork represents a putative event in Guillain–Barré syndrome (GBS) pathogenesis based on molecular mimicry between microbial lipooligosaccharides (LOS) and human peripheral nerve gangliosides. IgG antibodies produced against ganglioside‐like LOSs on bacterial surfaces attack mammalian gangliosides expressed at the node of Ranvier, leading to the onset of GBS causing axonal neuropathy. More information can be found in the Full Paper by A. Imamura, H. Ishida, et al. on page 796 .