Diagnostic and Therapeutic Uptake of Intrathyroid Metastasis of Midgut Neuroendocrine Tumor on 68Ga-DOTANOC PET/CT and 177Lu-DOTATATE Imaging. (July 2019)

• Record Type: Journal Article
• Authors: Vija Racaru, Lavinia; Sinigaglia, Mathieu; Fontaine, Sebastien; D'Aure, Dominique; Courbon, Frederic; Dierickx, Lawrence
• Is Part Of: Clinical nuclear medicine. Volume 44:Number 7(2019)
• Publication Date: 2019-07
• Subjects: Ga PET/CT -- somatostatin analog imaging -- thyroid metastasis -- neuroendocrine tumor -- Lu therapy; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000002586
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: A 58-year-old woman with 5-year history of grade 1 progressive metastatic intestinal neuroendocrine tumor with metachronous liver metastases initially treated by surgery and liver embolization underwent 68 Ga-DOTANOC PET/CT before 177 Lu-DOTATATE therapy. 68 Ga-DOTANOC PET/CT revealed increased uptake in several liver metastases and right iliac lymph nodes, consistent with radiopeptide therapy, including a hypodense isthmic thyroid nodule. Fine needle ultrasound-guided biopsy of the thyroid nodule was realized. Immunohistochemistry was positive for CD56, chromogranin, and synaptophysin and negative for calcitonin, confirming neuroendocrine tumor intrathyroid metastasis. 177 Lu-DOTATATE SPECT/CT showed therapeutic uptake on the thyroid metastasis.