Exercise-Induced Mitophagy in Skeletal Muscle and Heart. Issue 3 (July 2019)

• Record Type: Journal Article
• Authors: Guan, Yuntian; Drake, Joshua C.; Yan, Zhen
• Is Part Of: Exercise and sport sciences reviews. Volume 47:Issue 3(2019:Jul.)
• Publication Date: 2019-07
• Subjects: mitophagy -- mitochondrial reticulum -- exercise -- skeletal muscle -- cardiomyocyte; Sports -- Physiological aspects -- Periodicals; Exercise -- Physiological aspects -- Periodicals; Sports medicine -- Periodicals; 612.76
• DOI: 10.1249/JES.0000000000000192
• Languages: English
• ISSNs: 0091-6331

Abstract

Abstract : Regular exercise enhances mitochondrial function by promoting healthy mitochondrial remodeling, but the underlying mechanisms are not thoroughly understood. An emerging hypothesis suggests that, in addition to anabolic events such as mitochondria biogenesis, the selective degradation of dysfunctional mitochondria ( i.e., mitophagy) also is a key component of exercise-mediated adaptations in striated muscle, which eventually leads to better mitochondrial functions. Abstract : Mitophagy is a key component in exercise-induced adaptations at the mitochondrial reticulum in both skeletal muscle and heart.