Cerebellar Microbleed Distribution Patterns and Cerebral Amyloid Angiopathy: A Magnetic Resonance Imaging and Pathology-Based Study. Issue 7 (July 2019)

• Record Type: Journal Article
• Authors: Pasi, Marco; Pongpitakmetha, Thanakit; Charidimou, Andreas; Singh, Sanjula D.; Tsai, Hsin-Hsi; Xiong, Li; Boulouis, Gregoire; Warren, Andrew D.; Rosand, Jonathan; Frosch, Matthew P.; Viswanathan, Anand; Gurol, M. Edip; Greenberg, Steven M.
• Is Part Of: Stroke. Volume 50:Issue 7(2019)
• Publication Date: 2019-07
• Subjects: cerebral amyloid angiopathy -- cerebral hemorrhage -- cerebellum; Cerebrovascular disease -- Periodicals; Cerebral circulation -- Periodicals; 616.81
• DOI: 10.1161/STROKEAHA.119.024843
• Languages: English
• ISSNs: 0039-2499

Abstract

Abstract : Background and Purpose—: Hematoma location within the cerebellum may help identify the dominant small vessel disease type (cerebral amyloid angiopathy [CAA] versus nonamyloid small vessel disease). However, it is unknown whether this holds true for cerebral microbleeds (CMBs) within the cerebellum. We tested the hypothesis that cerebellar CMBs restricted to the cortex and vermis (defined as superficial regions) are associated with clinically diagnosed and pathology-verified CAA. Methods—: Three hundred and seven consecutive spontaneous intracerebral hemorrhage (ICH) patients with a baseline magnetic resonance imaging that included susceptibility-weighted imaging or angiography were enrolled. Using a topographical template, cerebellar CMB patterns were defined as strictly superficial versus deep (cerebellar gray nuclei and white matter) or mixed (both regions involved). Thirty-six ICH patients with cerebellar CMBs and neuropathology data available were evaluated for the presence of CAA. Results—: One hundred and thirty-five (44%) ICH patients had CMBs in the cerebellum. In the patient group with cerebellar CMBs, 85 (63%) showed a superficial pattern, and 50 (37%) had a deep/mixed pattern. Strictly superficial cerebellar CMBs were independently associated with a supratentorial pattern of probable CAA-ICH according to the Boston criteria (odds ratio, 1.6; CI, 1.03–2.5) and deep/mixed cerebellar CMBs with a pattern of deep/mixed ICH (odds ratio, 1.8; CI, 1.2–2.7). Pathologically verified CAA was present in 23 of 24 (96%) patients with superficial cerebellar CMBs versus 3 of 12 (25%) patients with deep/mixed cerebellar CMBs ( P <0.001). Conclusions—: In ICH patients, cerebellar CMBs are relatively common and often restricted to superficial regions. A strictly superficial distribution of cerebellar CMBs is associated with clinically diagnosed and pathologically verified CAA. Abstract : Supplemental Digital Content is available in the text.