Successful Whole Genome Sequencing-guided Treatment of Mycoplasma hominis Ventriculitis in a Preterm Infant. Issue 7 (July 2019)

• Record Type: Journal Article
• Authors: Scaggs Huang, Felicia A.; Mortensen, Joel; Skoch, Jesse; Andersen, Heidi; Staat, Mary Allen; Schaffzin, Joshua K.; Haslam, David B.
• Is Part Of: Pediatric infectious disease journal. Volume 38:Issue 7(2019)
• Publication Date: 2019-07
• Subjects: Mycoplasma hominis -- meningitis -- neonate -- whole genome sequencing -- 16S rRNA sequencing; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000002306
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : We report a case of Mycoplasma hominis ventriculitis in a preterm neonate that was successfully identified with 16S ribosomal RNA sequencing and whole genome sequencing after failure to detect the pathogen with conventional diagnostic methods. The infant required doxycycline with subsequent clearance of the infection and no evidence of drug toxicity.