Reducing Hematologic Toxicity With Short Course Postexposure Prophylaxis With Zidovudine for HIV-1 Exposed Infants With Low Transmission Risk. Issue 7 (July 2019)

• Record Type: Journal Article
• Authors: Nguyen, Thi Thanh Truc; Kobbe, Robin; Schulze-Sturm, Ulf; Blohm, Martin; Hollwitz, Bettina; Hertling, Sandra; Becker, Christina; Oommen, Prasad Thomas; Laws, Hans-Jürgen; Martignoni, Franca; Ole Jensen, Björn-Erik; Olah, Karen; Schmidtke, Susanne; Kreuels, Benno; Vasconcelos, Malte Kohns; Neubert, Jennifer
• Is Part Of: Pediatric infectious disease journal. Volume 38:Issue 7(2019)
• Publication Date: 2019-07
• Subjects: HIV-1 -- exposed but uninfected children -- postexposure prophylaxis -- prevention of mother-to-child-transmission -- zidovudine; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000002357
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Using retrospectively collected data from 383 infants born to HIV-1-infected mothers receiving antiretroviral therapy, we compared transmission rates and hematologic toxicity between infants receiving 2-week (short course) versus longer duration zidovudine postexposure prophylaxis. Short course resulted in lower hematologic toxicity without evidence of increased vertical transmission risk.