The next generation cohort: a description of a cohort at high risk for childhood onset type 2 diabetes. (6th August 2018)

• Record Type: Journal Article
• Authors: Jabar, F.; Colatruglio, S.; Sellers, E.; Kroeker, K.; Wicklow, B.
• Is Part Of: Journal of developmental origins of health and disease. Volume 10:Number 1(2019)
• Page Start: 24
• Page End: 30
• Publication Date: 2018-08-06
• Subjects: maternal diabetes, offspring, outcomes, type 2 diabetes; Developmental biology -- Periodicals; Embryology, Human -- Periodicals; Disease susceptibility -- Periodicals; Prenatal influences -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; 612.64
• DOI: 10.1017/S204017441800048X
• Languages: English
• ISSNs: 2040-1744

Abstract

Abstract: Children of mothers with youth-onset (<18 years) type 2 diabetes (T2D) are at increased risk of youth-onset T2D. In Canada, the highest reported prevalence of youth-onset T2D is in First Nation youth, some of whom harbor a unique genetic predisposition HNF1α polymorphism which has been associated with age of onset and clinical presentation. To describe the characteristics of the Next Generation birth cohort ( n =260) at 7–9 years ( n =88) and 14–16 years of age ( n =27). This is a cross-sectional study of offspring exposed in utero to T2D (Next Generation Birth Cohort). Annual assessments from age 7 include height and weight, and biochemical testing (glucose, insulin, lipids, HbA1c). Descriptive statistics were employed. χ 2 tests and repeated-measures ANOVA were used to compare categorical and continuous characteristics, respectively. In total, 11.9% of the total cohort have developed T2D. Of those 14–16.9 years of age, 16.0% have developed T2D. 92% of the offspring ages 7–9 and 70.3% of offspring ages 14–16 are overweight or obese. Children had a significantly higher body mass index z -score than adolescents (2.9 v . 1.5, P =0.001). Comparing the different HNF1α genotypes (G/G wildtype, G/S heterozygote, S/S homozygote); HbA1c (GG: 5.5% v . G/S: 5.7% v . S/S: 8.8%; P =0.0052), insulin (GG: 103 v . G/S: 202; P =0.05) and T2D status (G/G: 5.7% v . G/S: 28.1% v . S/S: 72.7%; P <0.0001) were significantly different between groups. T2D is very common among adolescents of mothers with youth-onset T2D. Early childhood obesity and the HNF1α G319S allele are associated with the incidence of T2D in the Next Gen offspring.