DSM outcomes of psychotic experiences and associated risk factors: 6-year follow-up study in a community-based sample. Issue 8 (13th August 2018)

• Record Type: Journal Article
• Authors: Kırlı, Umut; Binbay, Tolga; Drukker, Marjan; Elbi, Hayriye; Kayahan, Bülent; Keskin Gökçelli, Duygu; Özkınay, Ferda; Onay, Hüseyin; Alptekin, Köksal; van Os, Jim
• Is Part Of: Psychological medicine. Volume 49:Issue 8(2019)
• Page Start: 1346
• Page End: 1356
• Publication Date: 2018-08-13
• Subjects: Community-based population, -- family history of mental disorders, -- follow-up study, -- mood disorders, -- non-psychotic disorders, -- persistence of psychotic experiences, -- psychotic disorders, -- psychotic experiences, -- socio-demographic factors, -- type of psychotic experiences; Psychiatry -- Periodicals; Medicine and psychology -- Periodicals; Clinical psychology -- Periodicals; 616.89
• DOI: 10.1017/S0033291718001964
• Languages: English
• ISSNs: 0033-2917

Abstract

Abstract: Background: Psychotic experiences (PEs) may predict a range of common, non-psychotic disorders as well as psychotic disorders. In this representative, general population-based cohort study, both psychotic and non-psychotic disorder outcomes of PE were analysed, as were potential moderators. Methods: Addresses were contacted in a multistage clustered probability sampling frame covering 11 districts and 302 neighbourhoods at baseline ( n = 4011). Participants were interviewed with the Composite International Diagnostic Interview (CIDI) both at baseline and at 6-year follow-up. Participants with PE at baseline were clinically re-interviewed with the SCID-I at follow-up. The role of socio-demographics, characteristics of PE, co-occurrence of mood disorders and family history of mental disorders were tested in the association between baseline PE and follow-up diagnosis. Results: In the participants with baseline PE, the psychotic disorder diagnosis rate at follow up was 7.0% – much lower than the rates of DSM-IV mood disorders without psychotic features (42.8%) and other non-psychotic disorders (24.1%). Within the group with baseline PE, female sex, lower socio-economic status, co-occurrence of mood disorders, family history of a mental disorder and persistence of PE predicted any follow-up DSM diagnosis. Furthermore, onset of psychotic v. non-psychotic disorder was predicted by younger age (15–30 years), co-presence of delusional and hallucinatory PE and family history of severe mental illness. Conclusion: The outcome of PE appears to be a consequence of baseline severity of multidimensional psychopathology and familial risk. It may be useful to consider PE as a risk indicator that has trans-diagnostic value.