Reduction in insulin degludec dosing for multiple exercise sessions improves time spent in euglycaemia in people with type 1 diabetes: A randomized crossover trial. Issue 2 (14th October 2018)

• Record Type: Journal Article
• Authors: Moser, Othmar; Eckstein, Max L.; Mueller, Alexander; Birnbaumer, Philipp; Aberer, Felix; Koehler, Gerd; Sourij, Caren; Kojzar, Harald; Holler, Peter; Simi, Helmut; Pferschy, Peter; Dietz, Pavel; Bracken, Richard M.; Hofmann, Peter; Sourij, Harald
• Is Part Of: Diabetes, obesity & metabolism. Volume 21:Issue 2(2019)
• Page Start: 349
• Page End: 356
• Publication Date: 2018-10-14
• Subjects: exercise intervention -- insulin therapy -- type 1 diabetes; Diabetes -- Periodicals; Obesity -- Periodicals; Metabolism -- Disorders -- Periodicals; Clinical pharmacology -- Periodicals; 616.462
• DOI: 10.1111/dom.13534
• Languages: English
• ISSNs: 1462-8902

Abstract

Abstract : Aims: To compare the time spent in specified glycaemic ranges in people with type 1 diabetes (T1D) during 5 consecutive days of moderate‐intensity exercise while on either 100% or 75% of their usual insulin degludec (IDeg) dose. Materials and Methods: Nine participants with T1D (four women, mean age 32.1 ± 9.0 years, body mass index 25.5 ± 3.8 kg/m 2, glycated haemoglobin 55 ± 7 mmol/mol (7.2% ± 0.6%) on IDeg were enrolled in the trial. Three days before the first exercise period, participants were randomized to either 100% or 75% of their usual IDeg dose. Participants exercised on a cycle ergometer for 55 minutes at a moderate intensity for 5 consecutive days. After a 4‐week wash‐out period, participants performed the last exercise period for 5 consecutive days with the alternate IDeg dose. Time spent in specified glycaemic ranges, area under the curve and numbers of hypoglycaemic events were compared for the 5 days on each treatment allocation using a paired Students' t test, Wilcoxon matched‐pairs signed‐rank test and two‐way ANOVA. Results: Time spent in euglycaemia over 5 days was greater for the 75% IDeg dose versus the 100% IDeg dose (4008 ± 938 minutes vs. 3566 ± 856 minutes; P = 0.04). Numbers of hypoglycaemic events ( P = 0.91) and time spent in hypoglycaemia ( P = 0.07) or hyperglycaemia ( P = 0.38) was similar for both dosing schemes. Conclusions: A 25% reduction in usual IDeg dose around regular exercise led to more time spent in euglycaemia, with small effects on time spent in hypo‐ and hyperglycaemia.