Changes in arginine are inversely associated with type 2 diabetes: A case‐cohort study in the PREDIMED trial. Issue 2 (2nd October 2018)

• Record Type: Journal Article
• Authors: Yu, Edward; Ruiz‐Canela, Miguel; Razquin, Cristina; Guasch‐Ferré, Marta; Toledo, Estefania; Wang, Dong D.; Papandreou, Christopher; Dennis, Courtney; Clish, Clary; Liang, Liming; Bullo, Monica; Corella, Dolores; Fitó, Montserrat; Gutiérrez‐Bedmar, Mario; Lapetra, José; Estruch, Ramón; Ros, Emilio; Cofán, Montserrat; Arós, Fernando; Romaguera, Dora; Serra‐Majem, Lluis; Sorlí, Jose V.; Salas‐Salvadó, Jordi; Hu, Frank B.; Martínez‐González, Miguel A.
• Is Part Of: Diabetes, obesity & metabolism. Volume 21:Issue 2(2019)
• Page Start: 397
• Page End: 401
• Publication Date: 2018-10-02
• Subjects: cohort study -- dietary intervention -- insulin resistance -- observational study -- population study, type 2 diabetes; Diabetes -- Periodicals; Obesity -- Periodicals; Metabolism -- Disorders -- Periodicals; Clinical pharmacology -- Periodicals; 616.462
• DOI: 10.1111/dom.13514
• Languages: English
• ISSNs: 1462-8902

Abstract

Abstract : The associations between arginine‐based metabolites and incident type 2 diabetes (T2D) are unknown. We employed a case‐cohort design, nested within the PREDIMED trial, to examine six plasma metabolites (arginine, citrulline, ornithine, asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA] and N‐monomethyl‐l‐arginine [NMMA]) among 892 individuals (251 cases) for associations with incident T2D and insulin resistance. Weighted Cox models with robust variance were used. The 1‐year changes in arginine (adjusted hazard ratio [HR] per SD 0.68, 95% confidence interval [CI] 0.49, 0.95; Q4 vs. Q1 0.46, 95% CI 0.21, 1.04; P trend = 0.02) and arginine/ADMA ratio (adjusted HR per SD 0.73, 95% CI 0.51, 1.04; Q4 vs. Q1 0.52, 95% CI 0.22, 1.25; P trend = 0.04) were associated with a lower risk of T2D. Positive changes of citrulline and ornithine, and negative changes in SDMA and arginine/(ornithine + citrulline) were associated with concurrent 1‐year changes in homeostatic model assessment of insulin resistance. Individuals in the low‐fat‐diet group had a higher risk of T2D for 1‐year changes in NMMA than individuals in Mediterranean‐diet groups ( P interaction = 0.02). We conclude that arginine bioavailability is important in T2D pathophysiology.