Bone regeneration by calcium phosphate‐loaded carboxymethyl cellulose nonwoven sheets in canine femoral condyle defects. Issue 5 (28th September 2018)

• Record Type: Journal Article
• Authors: Sakamoto, Ayumi; Qi, Pan; Ohba, Shinsuke; Ohta, Seiichi; Hara, Yuichi; Ogawa, Takayuki; Tomokiyo, Masahiro; Sasaki, Akari; Takizawa, Harue; Mochizuki, Manabu; Ito, Taichi; Honnami, Muneki
• Is Part Of: Journal of biomedical materials research. Volume 107:Issue 5(2019)
• Page Start: 1516
• Page End: 1521
• Publication Date: 2018-09-28
• Subjects: carboxymethyl cellulose -- nonwoven sheet -- bone graft -- bFGF; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.b.34243
• Languages: English
• ISSNs: 1552-4973

Abstract

Abstract: The bone regeneration capacities of calcium phosphate (CaP)‐loaded carboxymethyl cellulose (CMC) nonwoven sheet (CMC/CaP) were evaluated using a dog lateral femoral condyle defect model. In addition, the effect of bFGF on bone regeneration when added to CMC/CaP sheet was investigated. The CMC and CMC/CaP sheets have high operability. The new bone formation rate in the CMC/CaP group was significantly higher than that in the control and CMC groups based on micro‐computed tomography and histological evaluation. In contrast, there was no significant difference between the CMC/CaP group and the CMC/CaP/f group. In conclusion, the CMC/CaP sheet has the ability to promote new bone formation and seems to be useful as a sheet‐shaped bone graft substitute. The effect of the auditioning signaling molecules to the CMC/CaP sheet, such as bFGF, requires further investigation. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1516–1521, 2019. Abstract :