Contributing factors of mortality in Prader–Willi syndrome. Issue 2 (19th December 2018)

• Record Type: Journal Article
• Authors: Proffitt, Jennifer; Osann, Kathryn; McManus, Barbara; Kimonis, Virginia E.; Heinemann, Janalee; Butler, Merlin G.; Stevenson, David A.; Gold, June‐Anne
• Is Part Of: American journal of medical genetics. Volume 179:Issue 2(2019)
• Page Start: 196
• Page End: 205
• Publication Date: 2018-12-19
• Subjects: cardiac and respiratory failure -- growth hormone -- mortality -- obesity -- Prader–Willi syndrome; Medical genetics -- Periodicals; 616.14205
• DOI: 10.1002/ajmg.a.60688
• Languages: English
• ISSNs: 1552-4825

Abstract

Abstract : Prader–Willi syndrome (PWS) is a multi‐system disorder resulting from a lack of paternal gene expression in the 15q11.2‐q13 region. Using databases compiled through response questionnaires completed by families known to the Prader‐Willi Syndrome Association (USA), this study tested the hypothesis that PWS genetic subtype, BMI, age of diagnosis, clinical symptoms, and growth hormone treatment differ among deceased and living individuals with PWS. Categorical and continuous variables were compared using chi‐square and two‐group t tests, respectively. Deceased individuals had higher rates of clinical features, including increased weight concerns, heart problems, sleep apnea, other respiratory complications, diabetes, osteoporosis, high pain tolerance, and severe skin picking, when compared to living individuals. Meanwhile, living individuals had higher rates of growth hormone use and early puberty. Obesity and subsequent consequences are the primary contributors to increased mortality in PWS. Additional emphasis on areas to decrease mortality is needed.