A Highly Efficient Synthesis of Pyrrolo[1, 2‐a]pyrimidine Derivatives Containing 1, 3‐Indandione Skeleton. Issue 25 (1st July 2019)

• Record Type: Journal Article
• Authors: Alizadeh, Abdolali; Ghasemzadeh, Hossein; Xiao, Hong‐Ping
• Is Part Of: ChemistrySelect. Volume 4:Issue 25(2019)
• Page Start: 7446
• Page End: 7449
• Publication Date: 2019-07-01
• Subjects: cyclization -- diamine -- ketene aminals -- nitro ketene dithioacetal -- nitrogen heterocycles -- pyrrolo[1, 2-a]pyrimidines -- ring contraction; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201901263
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: The pyrimidines fused with pyrrole ring, pyrrolopyrimidines, showed broad applicability in medicinal chemistry. Herein, we synthesized the new derivatives (8 examples) of pyrrolo[1, 2‐ a ]pyrimidine containing 1, 3‐indandione skeleton by the use of triethylammonium thiolates, methyl iodide, and ketene aminals via a one‐pot three‐component reaction. Abstract : A series of pyrrolo[1, 2‐ a ]pyrimidine containing 1, 3‐indandione skeleton have been synthesized through the bicyclization strategy, from triethylammonium thiolates, methyl iodide and ketene aminals via a one‐pot three component reaction. The reactions were carried out at room temperature in DMF overnight.