Anti‐resorptive effect of pamidronate on extraction socket wall in dogs. Issue 7 (12th May 2018)

• Record Type: Journal Article
• Authors: Cha, Jae‐Kook; Sun, Yoo‐Kyung; Kim, Myong Ji; Sanz, Mariano; Jung, Ui‐Won
• Is Part Of: Clinical oral implants research. Volume 29:Issue 7(2018)
• Page Start: 688
• Page End: 696
• Publication Date: 2018-05-12
• Subjects: animal experiment -- bisphosphonate -- extraction -- histology -- ridge preservation; Dental implants -- Research -- Periodicals; 617.69
• DOI: 10.1111/clr.13260
• Languages: English
• ISSNs: 0905-7161

Abstract

Abstract: Aim: The aim of this experimental in vivo investigation was to assess the anti‐resorptive effect of low concentration pamidronate on the buccal plate in fresh extraction sockets. Materials and methods: The distal roots of the third premolars were extracted bilaterally in six dogs. A collagen matrix loaded with either pamidronate (test group) or saline (control group) was positioned on the outer surface of buccal bone immediately after tooth extraction and subsequently covered with a coronally advanced flap. Histological and histomorphometric outcomes were evaluated 12 weeks later. Results: The mean vertical distance between the buccal and lingual bone crest differed significantly between the test and control groups (0.52 ± 0.43 and 2.21 ± 1.15 mm, respectively; p = .037). The width of the buccal bone 1 mm below the crest was significantly wider in the test group than the control group (4.68 ± 0.68 vs. 3.44 ± 0.60 mm, p < .001). Conclusions: Local application of pamidronate onto a collagen matrix may reduce the dimensional changes of the buccal bone plate both vertically and horizontally.