A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy. (July 2017)

• Record Type: Journal Article
• Authors: Petersson, Kristoffer; Kyroudi, Archonteia; Bourhis, Jean; Ceberg, Crister; Knöös, Tommy; Bochud, François; Moeckli, Raphaël
• Is Part Of: Physics and imaging in radiation oncology. Volume 3(2017)
• Page Start: 53
• Page End: 56
• Publication Date: 2017-07
• Subjects: Pareto -- Plan quality -- Clinical grading analysis -- Prostate; Radiotherapy -- Periodicals; Radiation dosimetry -- Periodicals; Cancer -- Imaging -- Periodicals; Oncology -- Periodicals; 615.842
• DOI: 10.1016/j.phro.2017.09.003
• Languages: English
• ISSNs: 2405-6316

Abstract

Abstract: We present a clinical distance measure for Pareto front evaluation studies in radiotherapy, which we show strongly correlates (r = 0.74 and 0.90) with clinical plan quality evaluation. For five prostate cases, sub-optimal treatment plans located at a clinical distance value of >0.32 (0.28–0.35) from fronts of Pareto optimal plans, were assessed to be of lower plan quality by our (12) observers (p < .05). In conclusion, the clinical distance measure can be used to determine if the difference between a front and a given plan (or between different fronts) corresponds to a clinically significant plan quality difference.