Redistributed versus homogenous radiotherapy dose for head and neck cancer; a treatment planning study. (July 2017)

• Record Type: Journal Article
• Authors: Heukelom, Jolien; Lamers, Emmy; Slooten, Erik; van Werkhoven, Erik; Rasch, Coen; Sonke, Jan-Jakob
• Is Part Of: Physics and imaging in radiation oncology. Volume 3(2017)
• Page Start: 17
• Page End: 20
• Publication Date: 2017-07
• Subjects: Head and neck cancer -- Radiotherapy -- Dose-painting -- Treatment planning; Radiotherapy -- Periodicals; Radiation dosimetry -- Periodicals; Cancer -- Imaging -- Periodicals; Oncology -- Periodicals; 615.842
• DOI: 10.1016/j.phro.2017.07.002
• Languages: English
• ISSNs: 2405-6316

Abstract

Abstract: Dose redistribution, where radio-resistant parts of the tumour are boosted while the border of the planning target volume receives a lower dose has the potential to increase local control in advanced head and neck squamous cell carcinoma (HNSCC). In this treatment planning study for 20 patients, standard radiotherapy (RT) of 70 Gy, was compared to redistributed RT following the ARTFORCE trial protocol (NCT01504815), i.e., a fluorodeoxyglucose-positron emission tomography (FDG-PET) based heterogeneous simultaneous-integrated-boost to a total dose of 64–84 Gy. Redistribution marginally increased the mean ipsilateral ⧹contralateral parotid dose by 1.55⧹0.55 Gy but not dose to other organs at risk.