Teixobactin as a scaffold for unlimited new antimicrobial peptides: SAR study. Issue 10 (1st June 2018)

• Record Type: Journal Article
• Authors: Abdel Monaim, Shimaa A.H.; Jad, Yahya E.; El-Faham, Ayman; de la Torre, Beatriz G.; Albericio, Fernando
• Is Part Of: Bioorganic & medicinal chemistry. Volume 26:Issue 10(2018)
• Page Start: 2788
• Page End: 2796
• Publication Date: 2018-06-01
• Subjects: Antimicrobial resistance -- Cyclic peptide -- Depsipeptide -- Gram-positive bacteria -- Solid-phase peptide synthesis; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2017.09.040
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Abstract: It looks that a new era of antimicrobial peptides (AMPs) started with the discovery of teixobactin, which is a "head to side-chain" cyclodepsipeptide. It was isolated from a soil gram-negative b-proteobacteria by means of a revolutionary technique. Since there, several groups have developed synthetic strategies for efficient synthesis of this peptide and its analogues as well. Herein, all chemistries reported as well as the biological activity of the analogues are analyzed. Finally, some inputs regarding new trends for the next generation of analogues are discussed.