A Bioelectronic Platform Modulates pH in Biologically Relevant Conditions. Issue 7 (28th January 2019)

• Record Type: Journal Article
• Authors: Strakosas, Xenofon; Selberg, John; Zhang, Xiaolin; Christie, Noah; Hsu, Peng‐Hao; Almutairi, Adah; Rolandi, Marco
• Is Part Of: Advanced science. Volume 6:Issue 7(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-01-28
• Subjects: bioelectronics -- pH -- protons; Science -- Periodicals; 505
• DOI: 10.1002/advs.201800935
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: Bioelectronic devices that modulate pH can affect critical biological processes including enzymatic activity, oxidative phosphorylation, and neuronal excitability. A major challenge in controlling pH is the high buffering capacity of many biological media. To overcome this challenge, devices need to be able to store and deliver a large number of protons on demand. Here, a bioelectronic modulator that controls pH using palladium nanoparticles contacts with high surface area as a proton storage medium is developed. Reversible electronically triggered acidosis (low pH) and alkalosis (high pH) in physiologically relevant buffer conditions are achieved. As a proof of principle, this new platform is used to control the degradation and fluorescence of acid sensitive polymeric microparticles loaded with a pH sensitive fluorescent dye. Abstract : A bioelectronic modulator controls pH using palladium nanoparticle contacts as a proton storage medium. This powerful tool achieves reversible electronically triggered acidosis and alkalosis in physiologically relevant buffer conditions.