Novel tumor necrosis factor-α induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression. (28th September 2018)

• Record Type: Journal Article
• Authors: Padmavathi, Ganesan; Banik, Kishore; Monisha, Javadi; Bordoloi, Devivasha; Shabnam, Bano; Arfuso, Frank; Sethi, Gautam; Fan, Lu; Kunnumakkara, Ajaikumar B.
• Is Part Of: Cancer letters. Volume 432(2018)
• Page Start: 260
• Page End: 271
• Publication Date: 2018-09-28
• Subjects: TNFAIP8 -- TIPE -- Cancer -- TNF-α -- NF-κB -- Angiogenesis -- Invasion -- Metastasis; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2018.06.017
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: The tumor necrosis factor (TNF)-α- induced protein 8 (TNFAIP8/TIPE) family is a death effector domain (DED)-containing protein family with four identified members: TNFAIP8 (TIPE), TNFAIP8L1 (TIPE1), TNFAIP8L2 (TIPE2), and TNFAIP8L3 (TIPE3). These proteins were found to play crucial roles in the regulation of immune homeostasis, inflammation, and cancer development. Intensive research in the past two decades revealed a strong correlation of TIPE proteins with the development of various cancers including cancers of the bladder, blood, bone, breast, cervix, colon, esophagus, endometrium, stomach, liver, lung, ovary, pancreas, prostate, and thyroid gland. Also, deregulation of these proteins was found to promote the essential hallmarks of cancer such as survival, tumor growth, proliferation, inhibition of apoptosis, angiogenesis, invasion, migration, and metastasis. Further, differential expression of these proteins in normal and cancer tissues and their association with tumor progression and prognosis signifies the potential diagnostic and prognostic values of TIPE proteins and their importance in cancer therapy. The current review summarizes the literature available thus far on the expression, function, and role of TIPE proteins in the development and maintenance of various cancers. Highlights: TNF-α-induced protein 8 (TNFAIP8/TIPE) family members play an important role in a wide variety of physiological processes. Their expression is also deregulated in diverse malignancies and mediates tumor initiation, promotion and progression. They may also have prognostic, diagnostic and therapeutic potential for cancer patients.