Ethnopharmacological approaches to Talinum paniculatum (Jacq.) Gaertn. - Exploring cardiorenal effects from the Brazilian Cerrado. (28th June 2019)

• Record Type: Journal Article
• Authors: Tolouei, Sara Emilia Lima; Palozi, Rhanany Alan Calloi; Tirloni, Cleide Adriane Signor; Marques, Aline Aparecida Macedo; Schaedler, Maysa Isernhagen; Guarnier, Lucas Pires; Silva, Aniely Oliveira; de Almeida, Valter Paes; Manfron Budel, Jane; Souza, Roosevelt Isaias Carvalho; dos Santos, Ariany Carvalho; Silva, Denise Brentan; Lourenço, Emerson Luiz Botelho; Dalsenter, Paulo Roberto; Gasparotto Junior, Arquimedes
• Is Part Of: Journal of ethnopharmacology. Volume 238(2019)
• Publication Date: 2019-06-28
• Subjects: Diuretic -- Mesenteric vascular bed -- Potassium channels -- Talinaceae; 4-AP 4-aminopyridine -- ACh acetylcholine chloride -- ANOVA analysis of variance -- AP arterial pressure -- Ca+2 calcium -- Cl− chloride -- CaCl2 calcium chloride -- CO2 carbon dioxide -- CVD cardiovascular disease -- DBP diastolic blood pressure -- DAD diode array detector -- EDS energy disperse system -- EDTA ethylenediaminetetraacetic acid -- EI excretion load -- ESTP ethanol soluble fraction from Talinum paniculatum -- FAA formalin-acetic acid-alcohol -- FESEM field emission scanning electron microscopy -- GFR glomerular filtration rate -- GLB glibenclamide -- HCl hydrogen chloride -- HCTZ hydrochlorothiazide -- HR heart rate -- K+ potassium -- KCl potassium chloride -- KH2PO4 Monopotassium phosphate -- L-NAME Nω-Nitro-L-arginine methyl ester -- MAP mean arterial pressure -- MgSO4 magnesium sulfate -- MVB mesenteric vascular bed -- Na+ sodium -- NaCl sodium chloride -- NaHCO3 sodium bicarbonate -- OECD Organisation for Economic Co-operation and Development -- pH potential of hydrogen -- Phe phenylephrine -- PP perfusion pressure -- PSS physiological saline solution -- S.E.M. standard error of the mean -- SBP systolic blood pressure -- SK KCa small conductance calcium-activated potassium channels -- UEPG State University of Ponta Grossa -- UFGD Federal University of Grande Dourados -- UFPR Federal University of Paraná; Ethnopharmacology -- Periodicals; Pharmacognosy -- Periodicals; Herbs -- Periodicals; Herbs -- Periodicals; Pharmacognosy -- Periodicals; Pharmacognosie -- Périodiques; Herbes -- Périodiques; 615.1
• DOI: 10.1016/j.jep.2019.111873
• Languages: English
• ISSNs: 0378-8741

Abstract

Abstract: Ethnopharmacological relevance: Talinum paniculatum (Jacq.) Gaertn. (Talinaceae), popularly known as "major gomes" and "erva gorda", is a non-conventional food plant extensively distributed throughout the Brazilian territory. In Brazilian folk medicine, this species is used as aphrodisiac, to treat gastrointestinal problems, and as a cardioprotective agent. However, there are no reports in the literature proving its cardiovascular effects. Aim: To perform a whole-ethnopharmacological investigation of the cardiorenal properties of the ethanol soluble fraction from T. paniculatum (ESTP) in Wistar rats. Material and methods: First, plant samples were collected, properly identified and a morpho-anatomical characterization was carried out to provide quality control parameters. Then, ESTP was obtained and its chemical profile was determined by LC-DAD-MS. In addition, an acute toxicity assay was conducted in female Wistar rats in order to observe any toxic effects after one single administration. Finally, the diuretic and hypotensive potential of ESTP (30, 100 and 300 mg/kg) were investigated in male rats followed by the evaluation of its possible effects on peripheral vascular resistance. Results: Chemical compounds identified from ESTP were chlorogenic acids, amino acids, nucleosides, O -glycosylated flavones and organic acids. No signs of toxicity as well as no changes in urine volume or electrolyte elimination were observed after ESTP acute treatment. On the other hand, prolonged treatment with all doses of ESTP significantly increased urine volume and electrolyte excretion (Na +, K + and Cl − ) without affecting blood pressure or heart rate. Apparently, these effects are involved with the activation of the small conductance calcium-activated potassium channels contributing to the increase of renal blood flow and glomerular filtration rate. Conclusion: Data presented show important information about the ethnomedicinal properties of T. paniculatum . In addition, the study presents the ESTP as a possible herbal medicine, especially when a sustained diuretic effect is required. Graphical abstract: Image 1