A fatal case of self-poisoning through the ingestion of oleander leaves. (July 2019)

• Record Type: Journal Article
• Authors: Azzalini, Elena; Bernini, Marzia; Vezzoli, Sara; Antonietti, Anna; Verzeletti, Andrea
• Is Part Of: Journal of forensic and legal medicine. Volume 65(2019)
• Page Start: 133
• Page End: 136
• Publication Date: 2019-07
• Subjects: Medical jurisprudence -- Periodicals; Forensic sciences -- Periodicals; Forensic Medicine -- Periodicals; Médecine légale -- Périodiques; Electronic journals; 614.1
• DOI: 10.1016/j.jflm.2019.05.016
• Languages: English
• ISSNs: 1752-928X

Abstract

Abstract: Background: Benefits and even dangers of plants are known since time began. The ancients used plants and herbs because of their effects on the human body. Poisoning is a logical consequence of their use: history is full of episodes of plants and herbs poisoning, whether intentional or accidental. Aim: Oleander poisoning is generally accidental; an intentional assumption of its leaves to commit suicide is uncommon because the population is not aware of the harmfulness of its cardiotoxic glycosides, therefore we report a fatal case of self-poisoning through the voluntary ingestion of oleander leaves. Methods: A diagnosis of oleander self-poisoning was highly suspected on the basis of the circumstantial evidence and the autopsy findings. Toxicological investigations were performed on the samples collected during the autopsy and aimed at confirm the presence of oleandrin at a toxic level. Results: The autopsy revealed a piece of oleander leaf on the posterior third of the tongue's body and several plant residues, similar to the one recovered on the tongue, into the gastric content; petechiae on the deep surface of the scalp, multi-organ congestion, and pulmonary edema were also observed. The histological study corroborated the pulmonary edema macroscopically observed but did not provide any other information. The detection of oleandrin in biological cadaveric samples revealed high, fatal, concentrations. Conclusions: Cases of voluntary ingestion of oleander with a suicidal intent prove to be uncommon: in the case reported the victim was aware about the possibility to commit suicide through the ingestion of oleander leaves. Highlights: Oleander contains, in each of its parts, several cardiotoxic glycosides. We report a fatal case of self-poisoning through the ingestion of oleander leaves. The detection of oleandrin in cadaveric samples revealed fatal concentrations. The harmfulness of cardiotoxic glycosides is not well-known. The victim was aware of the possibility to commit suicide through oleander.