Is Subcutaneous Route an Alternative to Intravenous Route for Mouse Contrast-Enhanced Magnetic Resonance Imaging at 1.5 T?. (13th June 2019)

• Record Type: Journal Article
• Authors: Dillenseger, Jean-Philippe; Goetz, Christian; Sayeh, Amira; Zorn, Pierre-Emmanuel; Kremer, Stéphane; Rémond, Yves; Constantinesco, André; Aubertin-Kirch, Gaëlle; Choquet, Philippe
• Other Names: Wang Yi Academic Editor.
• Is Part Of: Concepts in magnetic resonance. Volume 2019(2019)
• Publication Date: 2019-06-13
• Subjects: Magnetic resonance -- Periodicals; Nuclear magnetic resonance -- Periodicals; 538
• DOI: 10.1155/2019/7428904
• Languages: English
• ISSNs: 1546-6086

Abstract

Abstract : The present work compares intravenous (IV) and subcutaneous (SC) routes for contrast-enhanced MRI (CE-MRI) in mice. For that purpose, we selected two contrast media used in clinical practice. MRI acquisitions were performed at 1.5 T on five adult mice (Swiss, 41 g +/- 3 g). On each animal, four acquisitions were achieved with IV and SC administration of either Gd-DOTA or MS-325 (1 acquisition per week). For each route, 0.1 mL of NaCl and 0.1 mL of contrast agent were injected. For each acquisition, 200 T1-weighted images were acquired in a 2 h 34 min time lapse. For each route and contrast medium, dynamic contrast enhancement (DCE) curves were obtained. Time-to-peak (TTP), uptake, and washout constant-time values and contrast-to-noise ratio (CNR) were extracted. IV route TTP value was 4.9 min with Gd-DOTA and 5.4 min with MS-325. SC route TTP was 43.3 min with Gd-DOTA and 45.0 min with MS-325. Despite slower uptake constant-time, we show that SC is a potentially valuable alternative to the IV route in mouse preclinical CE-MRI.