Fabrication of the Enzyme‐less Voltammetric Bilirubin Sensor Based on Sol‐gel Imprinted Polymer. Issue 3 (30th October 2019)

• Record Type: Journal Article
• Authors: Akhoundian, Maedeh; Alizadeh, Taher; Pan, Guoqing
• Is Part Of: Electroanalysis. Volume 32:Issue 3(2020)
• Page Start: 479
• Page End: 488
• Publication Date: 2019-10-30
• Subjects: Bilirubin -- Carbon paste electrode -- Sol-gel imprinted polymer -- Voltammetric sensor -- Nanoparticles; Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.201900410
• Languages: English
• ISSNs: 1040-0397

Abstract

Abstract: Measuring the serum bilirubin (BR) level is part of the common test for newborns, since high concentrations of bilirubin in the blood can cause brain damage and even death for them. Therefore, achieving a fast, accurate and cost effective method for bilirubin assay in medical diagnosis and Medical management of patients with jaundice, especially neonates, is very important. In this study, an electrochemical sensor was developed to detect low amounts of bilirubin in serum samples. The basis of the work is the BR imprinted polymer synthesis and the use of this polymer as a recognition element in the production of the bilirubin voltammetric sensor. For this purpose, bilirubin imprinted polymer was synthesized using the simple sol gel method and the prepared polymer is characterized by SEM and FT‐IR. In the next step, this polymer was applied to modify the carbon paste electrode and provide a sensitive and selective sensor for the BR molecule. The proposed sensor was able to measure the bilirubin in the concentration range of 1 to 100 μM after optimizing the operating conditions. The limit of detection (LOD) and limit of quantification (LOQ) was calculated 0.75 μM and 2.5 μM respectively. It is also applicable to bilirubin assay in serum samples. Abstract :