Cerebellar Ataxia Followed by Stiff Person Syndrome in a Patient with Anti-GAD Antibodies. (8th February 2020)

• Record Type: Journal Article
• Authors: Seneviratne, Sinali O.; Buzzard, Katherine A.; Cruse, Belinda; Monif, Mastura
• Other Names: Pignata Claudio Academic Editor.
• Is Part Of: Case reports in immunology. Volume 2020(2020)
• Publication Date: 2020-02-08
• Subjects: Immunology -- Periodicals; Immunology -- Case studies -- Periodicals; Immune System Phenomena; Immunology; Immunology; Case studies; Periodicals; 571.96
• DOI: 10.1155/2020/8454532
• Languages: English
• ISSNs: 2090-6609

Abstract

Abstract : Anti-GAD antibody syndrome is a result of the production of antibodies against glutamic acid decarboxylase (GAD), the main enzyme responsible for the production of gamma-aminobutyric acid (GABA). Several neurological manifestations including cerebellar ataxia and stiff person syndrome have been reported in association with anti-GAD antibodies. In this paper, we present a case of a young woman with anti-GAD antibodies who initially presented with cerebellar ataxia followed by stiff person syndrome three and a half years later. Having both cerebellar ataxia and stiff person syndrome is a rare occurrence in anti-GAD antibody syndrome. We emphasise the importance of long-term follow-up of patients with anti-GAD antibody syndrome, as delayed neurological manifestations can occur.