From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins: the chemical biology of Ahp-cyclodepsipeptides. Issue 2 (27th August 2019)

• Record Type: Journal Article
• Authors: Köcher, Steffen; Resch, Sarah; Kessenbrock, Till; Schrapp, Lukas; Ehrmann, Michael; Kaiser, Markus
• Is Part Of: Natural product reports. Volume 37:Issue 2(2020)
• Page Start: 163
• Page End: 174
• Publication Date: 2019-08-27
• Subjects: Natural products -- Periodicals; Produits naturels -- Périodiques; 547.7
• DOI: 10.1039/c9np00033j
• Languages: English
• ISSNs: 0265-0568

Abstract

Abstract : Ahp-cyclodepsipeptides (also known as Ahp-containing cyclodepsipeptides, cyanopeptolins, micropeptins, microginines, and lyngbyastatins, and by many other names) are a natural product family with potent serine protease inhibitory properties. Abstract : Covering: 1989 up to 2019 Ahp-cyclodepsipeptides (also known as Ahp-containing cyclodepsipeptides, cyanopeptolins, micropeptins, microginines, and lyngbyastatins, and by many other names) are a family of non-ribosomal peptide synthesis (NRPS)-derived natural products with potent serine protease inhibitory properties. Here, we review their isolation and structural elucidation from natural sources as well as studies of their biosynthesis, molecular mode of action, and use in drug discovery efforts. Accordingly, this summary aims to provide a comprehensive overview of the current state-of-the-art Ahp-cyclodepsipeptide research.