Multiple sclerosis prevalence in 2000 and 2010 in Western Finland. (2nd January 2020)

• Record Type: Journal Article
• Authors: Murtonen, Annukka; Sumelahti, Marja‐Liisa
• Is Part Of: Acta neurologica Scandinavica. Volume 141:Number 4(2020)
• Page Start: 311
• Page End: 318
• Publication Date: 2020-01-02
• Subjects: disease course -- epidemiology -- multiple sclerosis -- prevalence -- sex; Neurology -- Periodicals; 616.8
• DOI: 10.1111/ane.13203
• Languages: English
• ISSNs: 0001-6314

Abstract

Abstract : Objective: To study ten‐year change in MS prevalence in the Province of Western Finland in Tampere University Hospital District located in 62.7°N, 23.7°E. Methods: Age‐standardized prevalence/10 5 by using direct standardization in European Standard Population (ESP2013) and crude prevalence/10 5 with 95% confidence interval (95% CI) were assessed among resident MS cases fulfilling Poser criteria by sex and disease course in 31.12.2000 and 31.12.2010. MS‐related disability and disease‐modifying treatment (DMT) use were estimated in 31.12.2010. Results: Crude prevalence increased 49% from 129/10 5 (95% CI 121‐137) in 2000 (N 1080) to 196/10 5 (187‐203) in 2010 (N 1666). Age‐standardized prevalence increased 45% from 133/10 5 (127‐140) to 192/10 5 (184‐200) and peaked in 40‐ to 49‐year age‐group. Age‐standardized prevalence increased 58% among women from 176/10 5 (171‐176) to 277/10 5 (270‐284) and 31% among men from 91/10 5 (87‐95) to 119/10 5 (115‐124). Increase in RRMS was 61% from 111/10 5 (105‐117) to 179/10 5 (171‐186), and decrease in PPMS was 14% from 21/10 5 (19‐24) to 18/10 5 (15‐21). In 2010 among the 52% RRMS cases on DMT, MS‐related disability was mild in 50%. In total, cohort disability was mild in 46%, moderate to severe in 47%, and information was not available in 14%. Conclusion: A significant increase in prevalence was observed in Western Finland. Increase was higher among women and in relapsing‐remitting onset MS. Disability showed age‐ and disease course‐specific variation.