The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer. (17th December 2019)

• Record Type: Journal Article
• Authors: Lo, Pui-Chi; Rodríguez-Morgade, M. Salomé; Pandey, Ravindra K.; Ng, Dennis K. P.; Torres, Tomás; Dumoulin, Fabienne
• Is Part Of: Chemical Society reviews. Volume 49:Number 4(2020)
• Page Start: 1041
• Page End: 1056
• Publication Date: 2019-12-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cs00129h
• Languages: English
• ISSNs: 0306-0012

Abstract

Abstract : Due to their photoproperties and easy chemical functionalisations, phthalocyanines are amongst the most promising advanced photosensitisers for photodynamic therapy of cancer. Abstract : Phthalocyanines exhibit superior photoproperties that make them a surely attractive class of photosensitisers for photodynamic therapy of cancer. Several derivatives are at various phases of clinical trials, and efforts have been put continuously to improve their photodynamic efficacy. To this end, various strategies have been applied to develop advanced phthalocyanines with optimised photoproperties, dual therapeutic actions, tumour-targeting properties and/or specific activation at tumour sites. The advantageous properties and potential of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer are highlighted in this tutorial review.