Fertility‐sparing surgery and survival among reproductive‐age women with epithelial ovarian cancer in 2 cancer registries. Issue 6 (27th November 2019)

• Record Type: Journal Article
• Authors: Crafton, Sarah M.; Cohn, David E.; Llamocca, Elyse N.; Louden, Elaine; Rhoades, Jennifer; Felix, Ashley S.
• Is Part Of: Cancer. Volume 126:Issue 6(2020)
• Page Start: 1217
• Page End: 1224
• Publication Date: 2019-11-27
• Subjects: fertility preservation -- ovarian cancer -- reproductive function -- survival; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.32620
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : Background: This study examined predictors of fertility‐sparing surgery (FSS) among reproductive‐age women diagnosed with epithelial ovarian cancer (EOC). In addition, relationships between FSS and survival were assessed in models stratified by tumor characteristics. Methods: The Surveillance, Epidemiology, and End Results (SEER) program and the National Cancer Database (NCDB) were queried for women 44 years old or younger with a primary EOC. FSS included unilateral salpingo‐oophorectomy and uterine preservation, whereas surgeries including bilateral salpingo‐oophorectomy and hysterectomy were categorized as non‐FSS. Logistic regression was used to estimate multivariable‐adjusted odds ratios and 95% confidence intervals (CIs) for associations between clinical characteristics (eg, age at diagnosis and race) and FSS odds. Multivariable Cox regression was used to estimate hazard ratios (HRs) and 95% CIs for FSS and overall survival in subgroups defined by stage and grade or by stage and histology. Analyses were stratified by database (SEER vs NCDB). Results: This analysis included 9017 women (SEER, n = 3932; NCDB, n = 5085) with EOC diagnosed between the ages of 15 and 44 years. In both cohorts, factors associated with significantly higher FSS odds included a younger age, a more recent ovarian cancer diagnosis, and no adjuvant chemotherapy. FSS was significantly associated with lower overall survival among women with stage II to IV, serous EOC (SEER HR, 1.61; 95% CI, 1.22‐2.12). Significant associations between FSS and survival were not observed in other subgroups defined by stage and grade or by stage and histology. Conclusions: FSS appears to be safe for certain women with EOC but was related to poor survival among women with advanced‐stage, serous EOC. Confirmatory studies with information on fertility intentions are needed. Abstract : Fertility‐sparing surgery for ovarian cancer is associated with poor survival among women with advanced‐stage, serous epithelial ovarian cancer. No significantly increased risk of death associated with fertility‐sparing surgery has been observed for women with other tumor characteristics.