ANRIL and atherosclerosis. (8th November 2019)
- Record Type:
- Journal Article
- Title:
- ANRIL and atherosclerosis. (8th November 2019)
- Main Title:
- ANRIL and atherosclerosis
- Authors:
- Chen, Li
Qu, Hua
Guo, Ming
Zhang, Ying
Cui, Yuanyuan
Yang, Qiaoning
Bai, Ruina
Shi, Dazhuo - Abstract:
- Abstract: What is known and objective: The 3.8‐kb‐long antisense non‐coding RNA at the INK4 locus (ANRIL) is transcribed from the short arm of human chromosome 9 on P21 and is associated with malfunction of the vascular endothelium, vascular smooth muscle cell (VSMC) proliferation/migration/senescence/apoptosis, mononuclear cell adhesion and proliferation, glycolipid metabolism disorder and DNA damage. Hence, ANRIL plays an important role in atherogenesis. Moreover, genome‐wide association studies (GWAS) have identified ANRIL as a biomarker that is closely related to coronary heart disease (CHD). The objective of this review was to discuss the pathological mechanism of ANRIL in atherosclerotic development and its significance as a predictor of cardiovascular disease. Methods: Review of the PubMed, EMBASE and Cochrane databases for articles demonstrating the roles of ANRIL in the development of atherosclerotic diseases. Results and discussion: The abnormal expression of ANRIL is linked to vascular endothelium injury; the proliferation, migration, senescence and apoptosis of VSMCs; mononuclear cell adhesion and proliferation; glycolipid metabolism disorder; DNA damage; and competing endogenous RNAs. Moreover, ANRIL accelerates the progression of CHD by regulating its single nucleotide polymorphisms (SNPs). What is new and conclusion: Considering that ANRIL accelerates atherosclerosis (AS) development and is a risk factor for CHD, it is reasonable for us to explore anAbstract: What is known and objective: The 3.8‐kb‐long antisense non‐coding RNA at the INK4 locus (ANRIL) is transcribed from the short arm of human chromosome 9 on P21 and is associated with malfunction of the vascular endothelium, vascular smooth muscle cell (VSMC) proliferation/migration/senescence/apoptosis, mononuclear cell adhesion and proliferation, glycolipid metabolism disorder and DNA damage. Hence, ANRIL plays an important role in atherogenesis. Moreover, genome‐wide association studies (GWAS) have identified ANRIL as a biomarker that is closely related to coronary heart disease (CHD). The objective of this review was to discuss the pathological mechanism of ANRIL in atherosclerotic development and its significance as a predictor of cardiovascular disease. Methods: Review of the PubMed, EMBASE and Cochrane databases for articles demonstrating the roles of ANRIL in the development of atherosclerotic diseases. Results and discussion: The abnormal expression of ANRIL is linked to vascular endothelium injury; the proliferation, migration, senescence and apoptosis of VSMCs; mononuclear cell adhesion and proliferation; glycolipid metabolism disorder; DNA damage; and competing endogenous RNAs. Moreover, ANRIL accelerates the progression of CHD by regulating its single nucleotide polymorphisms (SNPs). What is new and conclusion: Considering that ANRIL accelerates atherosclerosis (AS) development and is a risk factor for CHD, it is reasonable for us to explore an efficacious ANRIL‐based therapy for AS in CHD. Abstract : The abnormal expression of ANRIL promotes the development of atherosclerosis and ANRIL is novel biomarker closely associted with coronary heart disease. … (more)
- Is Part Of:
- Journal of clinical pharmacy and therapeutics. Volume 45:Number 2(2020)
- Journal:
- Journal of clinical pharmacy and therapeutics
- Issue:
- Volume 45:Number 2(2020)
- Issue Display:
- Volume 45, Issue 2 (2020)
- Year:
- 2020
- Volume:
- 45
- Issue:
- 2
- Issue Sort Value:
- 2020-0045-0002-0000
- Page Start:
- 240
- Page End:
- 248
- Publication Date:
- 2019-11-08
- Subjects:
- ANRIL -- atherosclerosis -- biomarker -- mechanism
Clinical pharmacology -- Periodicals
Chemotherapy -- Periodicals
615 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2710 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1111/jcpt.13060 ↗
- Languages:
- English
- ISSNs:
- 0269-4727
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4958.685000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 12988.xml