MicroRNAs in breast cancer: Roles, functions, and mechanism of actions. Issue 6 (14th November 2019)

• Record Type: Journal Article
• Authors: Abolghasemi, Maryam; Tehrani, Sadra Samavarchi; Yousefi, Tooba; Karimian, Ansar; Mahmoodpoor, Ata; Ghamari, Aliakbar; Jadidi‐Niaragh, Farhad; Yousefi, Mehdi; Kafil, Hossein Samadi; Bastami, Milad; Edalati, Mahdi; Eyvazi, Shirin; Naghizadeh, Mohsen; Targhazeh, Niloufar; Yousefi, Bahman; Safa, Amin; Majidinia, Maryam; Rameshknia, Vahid
• Is Part Of: Journal of cellular physiology. Volume 235:Issue 6(2020:Jun.)
• Page Start: 5008
• Page End: 5029
• Publication Date: 2019-11-14
• Subjects: biomarker -- cancer -- diagnosis -- microRNAs -- prognosis -- signal pathway; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.29396
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Breast cancer is one of the most lethal malignancies in women in the world. Various factors are involved in the development and promotion of the malignancy; most of them involve changes in the expression of certain genes, such as microRNAs (miRNAs). MiRNAs can regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of cancer progression, particularly breast cancer. Besides, accumulating data demonstrated that miRNAs are a novel tool for prognosis and diagnosis of breast cancer patients. Herein, we will review the roles of these RNA molecules in several important signaling pathways, such as transforming growth factor, Wnt, Notch, nuclear factor‐κ B, phosphoinositide‐3‐kinase/Akt, and extracellular‐signal‐regulated kinase/mitogen activated protein kinase signaling pathways in breast cancer. Abstract : Various factors are involved in the development and promotion of breast cancer. MicroRNAs (miRNAs) regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of breast cancer progression. We review the roles of miRNAs in signaling pathways in breast cancer.