Synthesis, crystal and antiproliferative activity of 2-[2-(2-fluorobenzylidene) hydrazinyl]-4-(1-methyl-1H-indol-3-yl)thieno[3, 2-d]pyrimidine. (13th October 2019)

• Record Type: Journal Article
• Authors: Liu, Ju; Shi, Jian–Tao; Gong, Yi-Lin; Ding, Shi; Chen, Ye
• Is Part Of: Molecular crystals and liquid crystals. Volume 692(2019)
• Page Start: 53
• Page End: 61
• Publication Date: 2019-10-13
• Subjects: antiproliferative activity -- synthesis -- thieno[3, 2-d] pyrimidine -- X-ray diffraction; Molecular crystals -- Periodicals; Liquid crystals -- Periodicals; Liquid crystals; Molecular crystals; Periodicals; 548
• DOI: 10.1080/15421406.2019.1706268
• Languages: English
• ISSNs: 1542-1406

Abstract

Abstract: The title compound 2-[2-(2-fluorobenzylidene)hydrazinyl]-4-(1-methyl-1 H -indol-3-yl) thieno[3, 2-d]pyrimidine (C22 H16 FN5 S) was prepared and its structure was confirmed by IR, 1 H NMR, MS, elemental analyses and X-ray diffraction. The crystal of the title compound belongs to the monoclinic system, space group P21 /c with a = 14.4546(17) Å, b = 17.0895(19) Å, c = 17.9621(15) Å, α = 90°, β = 122.717(6), γ = 90°, V = 3733.1(7) Å 3, Z = 4, and R = 0.0412 for 4816 observed reflections with I > 2σ( I ). In addition, the compound possesses distinct effective inhibition on the proliferation of HT-29, A549 and MKN45 cell lines.