UDP-glucuronosyltransferase genetic variation in North African populations: a comparison with African and European data. (17th November 2018)

• Record Type: Journal Article
• Authors: Novillo, Apolonia; Gaibar, María; Romero-Lorca, Alicia; Chaabani, Hassen; Amir, Nadir; Moral, Pedro; Esteban, M. Esther; Fernández-Santander, Ana
• Is Part Of: Annals of human biology. Volume 45:Number 6/8(2018)
• Page Start: 516
• Page End: 523
• Publication Date: 2018-11-17
• Subjects: Glucuronidase -- UGTs -- pharmacogenetics -- genetic diversity -- risk-associated alleles; Human biology -- Periodicals; 612
• DOI: 10.1080/03014460.2018.1559354
• Languages: English
• ISSNs: 0301-4460

Abstract

Abstract: Background: Genetic variation in glucuronosyltransferases (UGT) is crucial in drug metabolism and risk of some diseases. Aim: To examine genetic variation in UGT in North African populations. Subjects and methods: Allele frequencies of SNPs UGT1A4 24Thr, UGT1A4 48Val, UGT2B15 85Tyr, UGT2B15 523Thr and UGT2B17 CNV deletion from Morocco, Algeria, Tunisia and Libya were compared to European and Sub-Saharan populations. Results: North Africans are the group with the highest genetic heterogeneity given by internal differences in the occurrence of UGT2B17 deletion, UGT1A4 48Val and UGT1A4 haplotypes. UGT2B15 SNPs differentiate Sub-Saharans from the rest of the populations. Conclusion: North African populations show a high frequency of carriers of UGT2B15 523Thr, a variant linked to an increased risk of prostate cancer. High Atlas Moroccans and Algerians show low frequency of UGT2B17 del, a variant associated with high concentrations of testosterone and oestradiol.