Opioid poisoning. (March 2020)

• Record Type: Journal Article
• Authors: Layne, Kerry; Wood, David M.
• Is Part Of: Medicine. Volume 48:Number 3(2020)
• Page Start: 211
• Page End: 213
• Publication Date: 2020-03
• Subjects: Morphine -- MRCP -- naloxone -- opiate -- opioids -- oxycodone; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Médecine factuelle -- Périodiques; Medicine; Periodicals; Electronic journals; Electronic journals; 610
• DOI: 10.1016/j.mpmed.2019.12.018
• Languages: English
• ISSNs: 1357-3039

Abstract

Abstract: Opioids are among the most commonly prescribed analgesic medications, and opioid toxicity is becoming an increasing problem across the world. Patients typically present with a triad of signs: reduced consciousness, miosis and a reduced respiratory rate with shallow breaths. Patients with significant opioid toxicity are at risk of airway compromise, and basic supportive measures should be performed. Naloxone is a non-selective μ-opioid receptor antagonist that competitively binds to the μ-opioid receptor and should be administered, ideally intravenously, to patients with significant opioid toxicity.